Synthesis and antioxidant capacity of novel stable 5-tellurofuranose derivatives.

نویسندگان

  • Elton L Borges
  • Marta T Ignasiak
  • Yuliia Velichenko
  • Gelson Perin
  • Craig A Hutton
  • Michael J Davies
  • Carl H Schiesser
چکیده

Novel stable tellurium-containing carbohydrate derivatives are prepared from hexitols and pentitols through a double nucleophilic substitution with NaHTe in PEG-400. These tellurosugars react at very high rates with two-electron oxidants, including hypochlorous and peroxynitrous acid, formed at sites of inflammation, and show considerable promise as protective agents against oxidative damage.

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عنوان ژورنال:
  • Chemical communications

دوره 54 24  شماره 

صفحات  -

تاریخ انتشار 2018